Which principle states that research-related risks must be outweighed by its potential benefits?

The principle that states research-related risks must be outweighed by its potential benefits is known as beneficence. This ethical principle emphasizes the importance of maximizing benefits while minimizing harm in research and medical practice. Beneficence obligates researchers to carefully consider the potential benefits of their studies, such as advances in medical knowledge or improvements in patient care, and to ensure that these benefits justify any risks that participants might face. This principle is foundational in ensuring ethical research practices, as it directly addresses the moral responsibility to enhance the welfare of participants and society as a whole.

In contrast, other principles relate to different aspects of ethical conduct. For instance, justice focuses on ensuring fair distribution of research burdens and benefits among different groups, while respect pertains to the autonomy and rights of individuals. Integrity emphasizes the importance of honesty and adherence to ethical standards in the conduct of research. Each principle plays a unique role in the ethical framework but beneficence specifically highlights the assessment of risk versus benefit in research.